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21c Museum Hotel Lexington is an 88 room boutique hotel, contemporary art museum, cultural center and home to Lockbox restaurant. Woven into the fabric of downtown Lexington, 21c welcomes both visitors and the local community to enjoy the curated exhibitions and cultural programming.
Nestled in downtown Louisville on historic West Main Street, along Museum Row, 21c Museum Hotel Louisville is a multi-venue contemporary art museum, an award-winning 91-room boutique hotel, and home to acclaimed Proof on Main restaurant. Stay with us and the iconic Red Penguin.